Day or night this solution applies easily and is clear and non-irritating . Don't be fooled by it's gentleness, as it really does the trick to dry up the blemishes, without harsh drying of skin or causing the blemish to percolate beneath the treatment. My 13 year old son , after much persuasion, gave it a try and now uses it daily. His skin has cleared up incredibly fast. Absolutely worth the price. Truly the best blemish treatment we have ever used. I wish it had been available during my teens, but it works wonderfully on my occasional adult breakout.