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I began using this at night for the last 7-8 weeks at the same time as 2 topical prescriptions from the derm (1 morning/1night) and it took about a month to see the amount of acne reduce significantly. I have acne exasperated by hormones around pms and it was almost impossible to control because I cant take anything oral for it due to sensitivities. Ive played with all 3 products to see what is most effective and if I don't use this serum along with my 2 prescription creams then the creams are not as effective...This serum really makes that much of a difference. On days the prescription night cream is drying me out too much I will use the serum alone and it continues to keep acne away. if I skip a day without the serum or cream I will have a breakout. Once your skin gets use to this I don't know if you can live without it if you adult acne. Stings slightly at times in the beginning but not enough to put you off. Almost like a reassurance that its penetrating. It comes in a glass bottle so be careful where you place it nightly and it comes out almost like a watery consistency. I layer it after moisturizer because I have sensitive skin and it will turn me slightly pink if I apply it before the moisturizer. This product is the worth the money ;)

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