This face cleanser works great with or without a Clarisonic. It removes mascara okay - waterproof will still require a makeup remover, of course. I wear a 12 hour foundation and this does a wonderful job of removing my makeup. I also use cleansing conditioners instead of shampoo but find that sometimes my scalp needs a deep clean--I use this and it is great for that (I wouldn't use it every time I shampoo since my hair is dry). I've used it to wash makeup brushes and it works well for that too. It does sting my eyes so watch out for that. All in all a great cleanser especially if you are ingredient-conscious!